Preimplantation Embryos Amplify Stress-Induced Changes in Sperm-Derived miRNA Content to Mediate Transgenerational Epigenetic Inheritance
Alexandre Champroux, Yang Tang, David A. Dickson, Alice Meng, Anne N. Harrington, Lucy Liaw, Matteo Jacopo Marzi, Francesco Nicassio, Thorsten M. Schlaeger, Larry A. Feig
This study shows that chronic stress in male mice reduces sperm miR-34c levels through astrocyte-derived exosomes, leading to transgenerational anxiety and reduced sociability in offspring.
Epigenetics · May 13, 2024Peer-reviewedGenetics