Joseph E. Powell

The paper estimates the joint distribution of effect size and MAF for genetic variants in 28 complex traits and detects widespread negative selection signatures.

The paper characterizes the transcriptome of human stem cell-derived retinal ganglion cells using single-cell RNA sequencing, identifying three subpopulations with varying maturity levels.

The paper reconstructs cell fate trajectories in hiPSC-derived cardiomyocytes using single-cell RNA-seq and identifies genes with dynamic roles in cardiovascular disease risk.

This study shows that multi-site regulation of gene expression leads to biased eQTL fine mapping and highlights the need for joint multi-site analysis to improve accuracy.