Han Sheng Chiu

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

This study shows glycaemic variability, not just hyperglycaemia, increases heart muscle dysfunction and myocardial injury risk in diabetes using genetic and experimental models.

Village in a dish: a model system for population-scale hiPSC studies

The paper demonstrates that village cultures of hiPSCs maintain consistent transcriptional profiles across uni- and village-cultured samples, enabling population-scale studies.

Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation

This study investigates how 3D chromatin organization changes during human endothelial cell differentiation and links these changes to gene expression and transcriptional regulation.

A pluripotent stem cell atlas of multilineage differentiation reveals TMEM88 as a developmental regulator of mammalian blood pressure

The paper creates an iPSC differentiation atlas and identifies TMEM88 as a regulator of mesendodermal development and blood pressure.

HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs

This study identifies HOPX as a molecular switch regulating cardiomyocyte progenitor and maturation gene programs, linking it to cardiac function and genetic variation.

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

The paper identifies cell type-specific genetic control of gene expression in fibroblasts and iPSCs using single-cell RNA sequencing and eQTL mapping.

Genotype-free demultiplexing of pooled single-cell RNA-Seq

scSplit demultiplexes pooled single-cell RNA-Seq samples using genetic differences inferred from the data, showing high accuracy and consistency with known truths.

Single-Cell Transcriptome Sequencing Of Human Induced Pluripotent Stem Cells Identifies Differentially Primed Subpopulations

The paper identifies four transcriptionally distinct subpopulations in human induced pluripotent stem cells using single-cell RNA sequencing and develops a machine learning method to classify and predict transitions between these states.

Cardiac differentiation at single cell resolution reveals a requirement of hypertrophic signaling for HOPX transcription

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.

Determining cell fate specification and genetic contribution to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution

The paper reconstructs cell fate trajectories in hiPSC-derived cardiomyocytes using single-cell RNA-seq and identifies genes with dynamic roles in cardiovascular disease risk.