Joseph C. Genereux

The paper shows that N-terminal trimming of mislocalized secretory proteins helps maintain proteostasis by reducing aggregation and preventing proteasomal degradation.

The paper measures Asp isomerization rates in proteins, finding that tau isomerizes faster than other proteins, possibly linked to Alzheimer's disease cognition.

This study uses proximity labeling to monitor protein import into the endoplasmic reticulum in living cells and identifies factors influencing ER protein import.