Author

Cheska Marie Galapate

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-7995-1663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Cosimo CommissoiD· 3 shared David A. ScottiD· 2 shared Karen Duong‐PolkiD· 2 shared Rabi MuradiD· 2 shared Swetha MagantiiD· 2 shared Yijuan ZhangiD· 2 shared Alicia Llorente LopeiD· 1 shared Andrew M. LowyiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersCancer Biology

Cosimo CommissoORCID

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4 papers

Recent·Most cited

PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer

Gurpreet K. Arora, Ryan M. Loughran, Kyanh Ly, Cheska Marie Galapate, Alicia Llorente Lope, Taylor R. Anderson, Cynthia Y. Zhang, Shea F. Grenier, Ling Li, Sophia Crabtree, Guillem Lambies, Chantal Pauli, David A. Scott, Yoav Altman, Benji Portillo, , Brooke M. Emerling

This study identifies PI5P4K as a regulator of iron homeostasis in pancreatic cancer cells, showing its role in metabolic fitness and tumor growth.

Cell Reports · Aug 29, 2025Peer-reviewedCancer Biology

The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer

Priyanka Gupta, Rabi Murad, Lily Ling, Yijuan Zhang, Karen Duong‐Polk, Swetha Maganti, Cheska Marie Galapate, Cosimo Commisso

This study shows that aging stromal cells in pancreatic cancer promote immune exclusion and metastasis, and that rejuvenating these cells can reverse these effects.

bioRxiv · May 8, 2025 · PreprintCancer Biology

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

Yijuan Zhang, Ling Li, Swetha Maganti, Jennifer L. Hope, Cheska Marie Galapate, Florent Carrette, Karen Duong‐Polk, Anindya Bagchi, David A. Scott, Andrew M. Lowy, Linda M. Bradley, Cosimo Commisso

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.

bioRxiv · Nov 29, 2024 · PreprintCancer Biology

Monitoring Protein Import into the Endoplasmic Reticulum in Living Cells with Proximity Labeling

Ziqi Lyu, Melody M. Sycks, Mateo F. Espinoza, Khanh K. Nguyen, Maureen R. Montoya, Cheska Marie Galapate, Liangyong Mei, Joseph C. Genereux

This study uses proximity labeling to monitor protein import into the endoplasmic reticulum in living cells and identifies factors influencing ER protein import.

ACS Chemical Biology · Jun 8, 2022Peer-reviewedMolecular Biology