Weizhi Chen

The paper introduces the Sentieon ctDNA pipeline for accurate and efficient small somatic variant calling from ctDNA sequencing data, showing improved accuracy over existing methods.

This paper develops an RNA-based panel to detect multiple cancer driver mutations in NSCLC, showing high specificity and sensitivity for SNVs, fusions, and expression, with improved detection limits compared to DNA-seq.

bMSI-CAST improves cfDNA MSI detection by enhancing locus selection, duplicate removal, and calling algorithm, achieving high accuracy in gastrointestinal cancer samples.