BiochemistryProtein SciencePeer-reviewed
Retracing the evolution of a modern periplasmic binding protein
Florian Michel, Sergio Romero‐Romero, Birte Höcker
This study reconstructs a single-lobed progenitor of a periplasmic binding protein by deconstructing a modern RBP, showing that recombination of its lobes restores function and structure.