Andexanet alfa-associated heparin resistance in cardiac surgery: mechanism and in vitro perspectives
Charlene Vongai Chabata, Haixiang Yu, Lei Ke, James W. Frederiksen, Prakash A. Patel, Bruce A. Sullenger, Nabil K. Thalji
This study investigates how andexanet alfa causes heparin resistance in cardiac surgery, showing it sequesters heparin-bound antithrombin and creates a triphasic response to heparin.
Arteriosclerosis Thrombosis and Vascular Biology · Nov 21, 2024Peer-reviewedBiochemistry