BiochemistryArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewed
Andexanet alfa-associated heparin resistance in cardiac surgery: mechanism and in vitro perspectives
Charlene Vongai Chabata, Haixiang Yu, Lei Ke…·Nabil K. Thalji
This study investigates how andexanet alfa causes heparin resistance in cardiac surgery, showing it sequesters heparin-bound antithrombin and creates a triphasic response to heparin.
12 citations