PhysiologyScience AdvancesPeer-reviewed
The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart
Kelsey H. Fisher‐Wellman, Richard D. Lutze, Logan G. Kirkland…·Brian C. Jensen
This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.