Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy
Julie Chassagne, Nathalie Da Silva, Ines Akrouf, Bruno Cadot, Laura Julien, Inès Barthélémy, Stéphane Blot, Caroline Le Guiner, Mai Thao Bui, Norma Beatriz Romero, Jeanne Lainé, France Piétri‐Rouxel, Pierre Meunier, Kamel Mamchaoui, Stéphanie Lorain, , Sofia Benkhelifa‐Ziyyat
This study identifies endosomal pathway dysfunction in DMD muscle cells and shows that Rab5 upregulation contributes to endosomal defects, which can be mitigated by Rab5 knock-down or dystrophin restoration.
American Journal Of Pathology · Jun 9, 2025Peer-reviewedPathology