Bruno Cadot

This study shows that GDF5 overexpression in DMD mdx mice improves muscle histology, reduces inflammation, and enhances microdystrophin gene therapy outcomes.

This study identifies GDF5 as a protective factor in ALS by restoring SMAD signaling and preserving motor unit integrity through gene delivery in a mouse model.

The paper generates and characterizes the first mouse model with a dominant-negative glycine substitution in collagen VI alpha chains, showing key disease features for therapeutic research.

This study identifies endosomal pathway dysfunction in DMD muscle cells and shows that Rab5 upregulation contributes to endosomal defects, which can be mitigated by Rab5 knock-down or dystrophin restoration.

IMPatienT is a web application that digitizes, processes, and explores multimodal patient data, enabling EDA and diagnosis suggestions through a modular architecture.

The paper investigates how BMP signaling, through the Smad1/5/8 inhibitor Dullard, regulates cardiac neural crest cell behavior and outflow tract septation in vertebrates.