Cancer BiologybioRxivPreprint
Activating RET Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer
Rozita Bagheri‐Yarmand, Gabriel M. Pagnotti, Joseph L. Kidd…·Theresa A. Guise
This study shows that activating RET mutations in medullary thyroid cancer (MTC) cells promote osteoblastic bone metastases by increasing osteoprotegerin (OPG), which inhibits bone resorption and is linked to poor patient survival.
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