Activating RET Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer
Rozita Bagheri‐Yarmand, Gabriel M. Pagnotti, Joseph L. Kidd, David Avila Ramirez, Trupti Trivedi, Leah Guerra, Zhongya Wang, Lucia Martinez Cruz, Jade M. Moehle, Yaashmin Shiny Jebaraj, Xinhai Wan, Jian H. Song, Roland L. Bassett, Sue-Hwa Lin, Mimi I-Nan Hu, , Theresa A. Guise
This study shows that activating RET mutations in medullary thyroid cancer (MTC) cells promote osteoblastic bone metastases by increasing osteoprotegerin (OPG), which inhibits bone resorption and is linked to poor patient survival.
bioRxiv · Jul 9, 2025 · PreprintCancer Biology