Author

Jonathan Townson

University of CambridgeORCID 0000-0002-5145-5289Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Maria J. Gomez-LamarcaiD· 2 shared Sarah J. BrayiD· 2 shared Carmen Santa-Cruz MateosiD· 1 shared Charalambos S. RoussosiD· 1 shared F Javier deHaro-ArbonaiD· 1 shared Sarah BalouliD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersDevelopmental Biology

Maria J. Gomez-LamarcaORCID

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2 papers

Recent·Most cited

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

F Javier deHaro-Arbona, Charalambos S. Roussos, Sarah Baloul, Jonathan Townson, Maria J. Gomez-Lamarca, Sarah J. Bray

The paper reveals that Notch transcription hubs form dynamically in nuclei and confer memory, with only a third progressing to transcription, influenced by a second signal.

eLife · Oct 31, 2023Peer-reviewedDevelopmental Biology

OptIC Notch reveals mechanism that regulates receptor interactions with CSL.

Jonathan Townson, Maria J. Gomez-Lamarca, Carmen Santa-Cruz Mateos, Sarah J. Bray

The paper uses an optogenetic approach to control Notch signaling and shows that the {Phi}W{Phi}P motif sequesters CSL in the cytoplasm, preventing target gene activation until NICD is released.

Development · May 12, 2023Peer-reviewedDevelopmental Biology