Charalambos S. Roussos

This study identifies that both sequence-specific DNA binding and disordered protein domains are required for pioneer-factor chromatin occupancy, with mitotic retention relying only on DNA binding.

The paper shows Notch signaling forms transcription hubs that regulate gene expression by correlating hub dynamics with transcription profiles.

The paper investigates changes in CSL transcription complex behavior under Notch active conditions using single molecule microscopy, finding increased binding and exploratory behavior.

The paper reveals that Notch transcription hubs form dynamically in nuclei and confer memory, with only a third progressing to transcription, influenced by a second signal.