Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation
Morgan E. McCartney, Gavin M. Wheeler, Audrey G. O’Neill, Jeet H. Patel, Zoey R. Litt, S. John Calise, Justin M. Kollman, Andrea Elizabeth Wills
The paper shows that IMPDH2 is required for tail regeneration in Xenopus tropicalis and forms filaments in regenerating tissue under high GTP demand.
bioRxiv · Jul 29, 2024 · PreprintDevelopmental Biology