Author

Audrey G. O’Neill

University of WashingtonORCID 0000-0003-3964-4236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:Xenopus· 1

Frequent Co-Authors

Andrea Elizabeth WillsiD· 2 shared Gavin M. WheeleriD· 2 shared Jeet H. PateliD· 2 shared Justin M. KollmaniD· 2 shared Morgan E. McCartneyiD· 2 shared Gardenia Sanchez-RamireziD· 1 shared S. John CaliseiD· 1 shared Zoey R. LittiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

Andrea Elizabeth WillsORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 9, 2025

An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis

Audrey G. O’Neill, Morgan E. McCartney, Gavin M. Wheeler…·Andrea Elizabeth Wills

This paper shows that an IMPDH2 variant linked to neurodevelopmental disorders disrupts purine biosynthesis and somitogenesis in Xenopus tropicalis by affecting filament assembly and GTP sensitivity.

DOI 10.1101/2025.05.09.652712

Xenopusproteomics

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Developmental BiologybioRxivPreprintJul 29, 2024

Appendage regeneration requires IMPDH2 and creates a sensitized environment for enzyme filament formation

Morgan E. McCartney, Gavin M. Wheeler, Audrey G. O’Neill…·Andrea Elizabeth Wills

The paper shows that IMPDH2 is required for tail regeneration in Xenopus tropicalis and forms filaments in regenerating tissue under high GTP demand.

2 citations

mouseexperimental assay

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