Metformin rescues muscle function in BAG3 myofibrillar myopathy models
Avnika Ashok Ruparelia, Emily A. McKaige, Caitlin Williams, Keith E. Schulze, Margit Fuchs, Viola M. J. Oorschot, Emmanuelle Lacène, Mirella Meregalli, Clara Lee, Rita J. Serrano, Emily C. Baxter, Keyne Monro, Yvan Torrente, Georg Ramm, Tanya Stojkovic, , Robert J. Bryson‐Richardson
This study identifies Metformin as a potential therapy for BAG3 myofibrillar myopathy by rescuing muscle function in zebrafish models and reducing protein aggregates in human cells.
Autophagy · Oct 8, 2020Peer-reviewedGenetics