Author

Emmanuelle Lacène

Assistance Publique – Hôpitaux de Paris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Organism:zebrafish· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Guy BrochieriD· 2 shared A. Madelaine· 1 shared Agathe FranckiD· 1 shared Aleksandra Nadaj‐PaklezaiD· 1 shared Anaïs Chanut· 1 shared Anaïs Fongy· 1 shared Anne BigotiD· 1 shared Anne‐Sophie ArmandiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Guy BrochierORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel variants in ryanodine receptor type 3 predispose to acute rhabdomyolysis due to impaired autophagy

Hortense de Calbiac, Laure Caccavelli, Solène Renault, Marine Madrange, Quentin Raas, Marjolène Straube, Guy Brochier, Emmanuelle Lacène, Anaïs Chanut, A. Madelaine, Clémence Labasse, Lylia Mekzine, Sebastián Montealegre, Nicolas Goudin, Aleksandra Nadaj‐Pakleza, , Pascale de Lonlay

This study identifies rare RYR3 variants causing recurrent rhabdomyolysis by impairing autophagy and mitochondrial function, highlighting RyR3's role in muscle stress adaptation.

medRxiv · Mar 3, 2026 · PreprintGenetic & Genomic Medicine

Metformin rescues muscle function in BAG3 myofibrillar myopathy models

Avnika Ashok Ruparelia, Emily A. McKaige, Caitlin Williams, Keith E. Schulze, Margit Fuchs, Viola M. J. Oorschot, Emmanuelle Lacène, Mirella Meregalli, Clara Lee, Rita J. Serrano, Emily C. Baxter, Keyne Monro, Yvan Torrente, Georg Ramm, Tanya Stojkovic, , Robert J. Bryson‐Richardson

This study identifies Metformin as a potential therapy for BAG3 myofibrillar myopathy by rescuing muscle function in zebrafish models and reducing protein aggregates in human cells.

Autophagy · Oct 8, 2020Peer-reviewedGenetics

Mechanosensitive clathrin platforms anchor desmin intermediate filaments in skeletal muscle

Agathe Franck, Jeanne Lainé, Gilles Moulay, Michaël Trichet, Christel Gentil, Anaïs Fongy, Anne Bigot, Sofia Benkhelifa-Ziyyat, Emmanuelle Lacène, Mai Thao Bui, Guy Brochier, Pascale Guicheney, Sabrina Sacconi, Vincent Mouly, Norma Romero, , Stéphane Vassilopoulos

This study shows that clathrin plaques and dynamin 2 anchor desmin intermediate filaments and regulate YAP signaling in skeletal muscle in response to mechanical cues.

bioRxiv · Jul 18, 2018 · PreprintCell Biology