Recapitulating Parkinson's pathology in human iPSC dopaminergic neurons reveals new mechanistic insights into Lewy body formation and heterogeneity.
Anne‐Laure Mahul‐Mellier, Lukas van den Heuvel, Maxime Teixeira, Manel L. N. Boussouf, Gaspard Oudinot, Amelie Thonet, Davide Speri, Yllza Jasiqi, Christina H. Ulrich, Razan Sheta, Walid Idi, Mary-Claude Croisier-Coeytaux, Stéphanie Clerc-Rosset, Jérôme Blanc, Graham William Knott, , Hilal Ahmed Lashuel
This study uses human iPSC-derived dopaminergic neurons to model Parkinson's Lewy body pathology without genetic modification, revealing mechanisms of aSyn aggregation and morphological diversity.
bioRxiv · Oct 26, 2025 · PreprintNeuroscience