Davide Speri

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

This study uses human iPSC-derived dopaminergic neurons to model Parkinson's Lewy body pathology without genetic modification, revealing mechanisms of aSyn aggregation and morphological diversity.