Lukas van den Heuvel

This paper uses cryo-ET to study amyloid fibrils in neurodegenerative brain tissue, revealing ultrastructural details of fibril polymorphs and their association with disease.

This study uses correlative light and electron microscopy to characterize the ultrastructural changes in tau fibrils during ghost tangle formation in Alzheimer's disease brain tissue.

This study uses correlative light and electron microscopy to analyze Lewy body pathology in Parkinson's and dementia with Lewy bodies, revealing regional differences in ultrastructure and mitochondrial changes.

The paper examines ultrastructural differences between somatic and neuritic Lewy body inclusions in Parkinson's disease using correlative light and electron microscopy.

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

This study shows synthetic alpha-synuclein fibrils can replicate in mice, causing MSA-like pathology and forming glial cytoplasmic inclusions.

This study uses human iPSC-derived dopaminergic neurons to model Parkinson's Lewy body pathology without genetic modification, revealing mechanisms of aSyn aggregation and morphological diversity.

This paper provides a protocol for correlative light and electron microscopy (CLEM) optimized for analyzing human brain tissue, enabling detailed ultrastructural analysis and characterization of subcellular features.