Author

Ee Lyn Lim

Immunology Frontier Research Center, The University of OsakaORCID 0000-0002-5173-2979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Atsushi TanakaiD· 2 shared Shimon SakaguchiiD· 2 shared Daron M. StandleyiD· 1 shared Diego DíeziD· 1 shared Fuminori SugiharaiD· 1 shared Mara Anaís Llamas-CovarrubiasiD· 1 shared Martin LozaiD· 1 shared Shunsuke TeraguchiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Atsushi TanakaORCID

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2 papers

Recent·Most cited

Loss of PI3Kδ activity drives autoimmune colitis by impairing extrathymic Treg differentiation

Ee Lyn Lim, Yamin Qian, Fuminori Sugihara, Atsushi Tanaka, Shimon Sakaguchi

This study shows that loss of PI3Kδ activity impairs extrathymic Treg differentiation in the colon, leading to autoimmune colitis.

European Journal of Immunology · Oct 1, 2025Peer-reviewedImmunology

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire

Mara Anaís Llamas-Covarrubias, Atsushi Tanaka, Martin Loza, Diego Díez, Zichang Xu, Ee Lyn Lim, Shunsuke Teraguchi, Shimon Sakaguchi, Daron M. Standley

The paper shows that ZAP-70 mutations in mice lead to a shift in T cell repertoires, with pathogenic Th17 cells resembling Tregs and contributing to autoimmune arthritis.

bioRxiv · Mar 1, 2024 · PreprintImmunology