Jayda B. Duvernay

α-Synuclein Seeding in Dopaminergic Neurons Transplanted into the Putamen of Parkinson's Disease Patients

The paper investigates whether α-synuclein seeding from host tissue contributes to Lewy pathology in dopaminergic neuron grafts in Parkinson's disease patients.

Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb

Proximity proteomics in PFF-seeded mouse olfactory bulb shows aggregated phospho-S129 alpha-synuclein mostly reprioritizes existing interactions toward axon-glia, myelin and proteostasis proteins, with a conserved 107-protein signature.

CD11b Activation Reduces Myeloid Brain Infiltration and Mitigates Synucleinopathy in a Model of Parkinson's Disease

This study shows that CD11b agonism with LA1 reduces microglial activation and myeloid cell infiltration, thereby mitigating synucleinopathy in a Parkinson's disease model.

Physiological alpha-synuclein S129 phosphorylation mediates postsynaptic and nuclear interactions in the human brain

The paper maps physiological alpha-synuclein S129 phosphorylation interactomes in the human brain and confirms their presence in healthy non-human primates.