Cancer BiologybioRxivPreprint
Landscape of reversion alterations in homologous recombination genes reveals evolutionary constraints
Brennan James Decker, Saumya Dushyant Sisoudiya, James Thornton…·Katherine L. Nathanson
The paper identifies reversion mutations in homologous recombination genes across cancers, showing they restore DNA repair and confer PARP inhibitor resistance through specific structural alterations.
DOI 10.64898/2026.05.19.726319