Arindam Datta

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex

The paper investigates how the BRCA1-A complex recognizes and cleaves K63-linked polyubiquitin chains, revealing structural and functional mechanisms involved in DNA damage response.

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells

The paper shows BRCA1-A complex restricts replication fork reversal in ATM-deficient cells, leading to hypersensitivity to Topoisomerase I inhibitors and resistance to PARP1 inhibitors.

Landscape of reversion alterations in homologous recombination genes reveals evolutionary constraints

The paper identifies reversion mutations in homologous recombination genes across cancers, showing they restore DNA repair and confer PARP inhibitor resistance through specific structural alterations.

53BP1 condensates function as bioreactors for NHEJ directed DNA repair and insulators to determine pathway choice

This study shows 53BP1 condensates drive NHEJ foci formation and function as bioreactors and insulators to enhance DNA repair and pathway selection.

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.