Angus Lindsay

The paper identifies ADSS1 as a suppressed metabolic control node in dystrophic muscle, showing its role in purine metabolism and its impact on inflammatory and adipogenic remodelling.

This study compares daily and weekly glucocorticoid dosing in mdx mice, showing weekly vamorolone improves muscle function while minimizing adverse effects on metabolism and the CNS.

This study shows that stress reveals impaired endocrine coordination of glucose metabolism in dystrophin deficiency, with interventions improving glucose control and muscle function.

This study develops an in vivo rheological method to assess skeletal muscle stiffness and elasticity in dystrophin-deficient mice, finding increased stiffness and impaired recovery in mdx mice.

This study shows that TDP-43 aggregation in skeletal muscle causes motor dysfunction and neurodegeneration, but clearance of the protein allows for functional recovery.

This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.