NeurosciencebioRxivPreprint
Skeletal muscle TDP-43 aggregation drives progressive motor dysfunction and neurodegeneration with potential for functional recovery after clearance
Shuzhao Zhuang, Nadia Hafizi Rastabi, Saeedeh Robatjazi…·Aaron Paul Russell
This study shows that TDP-43 aggregation in skeletal muscle causes motor dysfunction and neurodegeneration, but clearance of the protein allows for functional recovery.
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