BioinformaticsACS Pharmacology & Translational SciencePeer-reviewed
A Scalable 3D High-Content Imaging Protocol for Measuring a Drug Induced DNA Damage Response Using Immunofluorescent Sub-nuclear γH2AX Spots in Patient Derived Ovarian Cancer Organoids
Hakan Keles, Christopher Schofield, Helena Rannikmäe…·Lisa Mohamet
This paper develops a scalable 3D imaging protocol to measure DNA damage response in ovarian cancer organoids using γH2AX staining and shows its effectiveness with Etoposide treatment.