Richard M. Köhler

Beyond beta rhythms: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study

This study shows that aperiodic broadband power, not just beta oscillations, is linked to Parkinson's disease severity and is increased in the more affected hemisphere.

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease

This study shows that state-dependent deep brain stimulation in Parkinson's disease increases movement speed more effectively during fast movements, using machine learning to decode brain signals for real-time adjustments.

An organotypic in vitro model of human papillomavirus-associated precancerous lesions allowing automated cell quantification for preclinical drug testing

This paper develops an organotypic in vitro model of HPV-induced precancerous lesions and uses machine learning to automate cell quantification for drug testing.

Movement execution defines a distinct neural state in dyskinesia and enhances decoding

The paper identifies movement execution as a distinct neural state in Parkinson's dyskinesia, showing it enhances decoding of dyskinesia through specific oscillatory patterns.

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

This study identifies how dopamine and deep brain stimulation affect cortex-basal ganglia networks at different scales, showing distinct mesoscale effects and shared macroscale suppression of network synchrony.

Cortical beta oscillations map to shared brain networks modulated by dopamine

This study identifies a shared brain network modulated by dopamine that underlies beta oscillations, revealing their role in cortico-subcortical circuits beyond motor function.

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson's disease

This study investigates how dopamine and deep brain stimulation (DBS) affect neural dynamics in Parkinson's disease by measuring motor intention latency and oscillatory communication patterns.