Andrea A. Kühn

Probabilistic mouse-human brain correspondence by multimodal optimal transport

OTTER maps mouse and human brain regions using optimal transport, revealing evolutionary differences in association cortex and enabling cross-species predictions.

Beyond beta rhythms: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study

This study shows that aperiodic broadband power, not just beta oscillations, is linked to Parkinson's disease severity and is increased in the more affected hemisphere.

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease

This study shows that state-dependent deep brain stimulation in Parkinson's disease increases movement speed more effectively during fast movements, using machine learning to decode brain signals for real-time adjustments.

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing

This study uses exome sequencing to identify genetic variants in dystonia patients, finding 137 likely pathogenic variants in 51 genes and expanding the known phenotypic spectrum of dystonia-related genes.

Movement execution defines a distinct neural state in dyskinesia and enhances decoding

The paper identifies movement execution as a distinct neural state in Parkinson's dyskinesia, showing it enhances decoding of dyskinesia through specific oscillatory patterns.

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

This study identifies how dopamine and deep brain stimulation affect cortex-basal ganglia networks at different scales, showing distinct mesoscale effects and shared macroscale suppression of network synchrony.

Interrogating basal ganglia circuit function in Parkinson's disease and dystonia

The paper examines differences in GPi neuronal activity and synaptic plasticity in Parkinson's disease and dystonia, finding distinct patterns of oscillatory activity and plasticity associated with each disorder.

Deep brain stimulation device-specific artefacts in MEG recordings

This study compares DBS artefacts in MEG recordings using different DBS devices and cleaning methods, finding device-specific differences and potential spectral artefacts after cleaning.

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson's disease

This study investigates how dopamine and deep brain stimulation (DBS) affect neural dynamics in Parkinson's disease by measuring motor intention latency and oscillatory communication patterns.

Pallidal neuromodulation of the explore/exploit trade-off in decision-making

This study shows that neuromodulation of the globus pallidus interna affects exploration in decision-making tasks by altering evidence accumulation rates.

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

The paper correlates subthalamic beta bursts with dopamine-dependent motor symptoms in 106 Parkinson's patients using two methods, showing frequency-specific relationships and medication effects.

Persistent synaptic inhibition of the subthalamic nucleus by high frequency stimulation

This study examines synaptic dynamics in the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) during high frequency stimulation, finding sustained inhibitory effects in STN compared to SNr.

Single-neuron bursts encode pathological oscillations in Parkinson's disease and essential tremor

This study links single-neuron bursting to pathophysiological LFP oscillations in Parkinson's disease and essential tremor using intracranial recordings.

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease

This paper shows that average beta burst duration profiles reflect changes in the dynamics of beta oscillations between ON and OFF medication states in Parkinson's disease, linking them to motor impairment.

Movement decoding using spatio-spectral features of cortical and subcortical local field potentials

This paper develops a movement decoding pipeline using spatio-spectral features from cortical and subcortical signals, showing improved decoding with spatial information.

The sensitivity of ECG contamination to surgical implantation site in adaptive closed-loop neurostimulation systems

The paper investigates how implant location affects ECG contamination in neurostimulation systems, finding higher contamination in left-sided subclavicular implants compared to right-sided ones.

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

This paper compares electrocorticography (ECoG) and subthalamic local field potentials (LFP) for movement decoding in Parkinson's disease, finding ECoG superior and demonstrating the impact of PD pathophysiology on decoding performance.

Toward a unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

The paper identifies a common neural tract associated with treatment response in OCD patients undergoing DBS targeting different brain regions.

Deep Brain Stimulation: Imaging on a group level

This paper introduces Lead Group, a tool for group-level DBS imaging analysis, showing optimal DBS targets in the dorsolateral STN and a fiber bundle linked to clinical outcomes in Parkinson's disease.

Left prefrontal impact links subthalamic stimulation with depressive symptoms

This study links left prefrontal connectivity with worsening depressive symptoms after STN-DBS in Parkinson's Disease.

Deep Brain Stimulation induced normalization of the human functional connectome in Parkinson’s Disease

This study uses resting-state fMRI to show that deep brain stimulation (DBS) in Parkinson’s Disease modulates global brain connectivity, normalizing it toward healthy controls and altering specific network couplings.

Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor

This study identifies effective deep brain stimulation targets for essential tremor by analyzing structural and functional brain connectivity in patients.

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

The paper updates the Lead-DBS pipeline for DBS imaging and connectomics, demonstrating its application on clinical data and comparing preprocessing strategies.

Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity

The paper creates a composite atlas of subcortical brain structures for DBS targets using multimodal MRI, histology, and structural connectivity to improve electrode placement analysis.