A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease
Daniyal J. Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Laura Wilson, Benjamin Michael Davis, William J. Mason, Eva Maria Funk, Maria Kolatsi‐Joannou, Radu Polschi, Saif N. Malik, Benjamin J. Stewart, Karen L. Price, Hannah J Mitchell, , David Andrew Long
The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.
Disease Models & Mechanisms · Mar 21, 2025Peer-reviewedPathology