Edoardo Micotti

A harmonized phantom MRI quality control framework identifies sources of longitudinal and multi-site variability

This paper develops a harmonized MRI QC framework using phantoms to identify sources of variability across field strengths and sites, showing that field strength alone does not fully characterize MRI performance.

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

This study shows that defective cyclophilin A (PPIA) leads to TDP-43 proteinopathy, contributing to ALS and FTD by disrupting TDP-43 function and causing neurodegeneration.

A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

Role of misfolded tau in the onset and progression of brain toxicity after trauma

This study shows that misfolded tau from traumatic brain injury induces toxicity in C. elegans, suggesting it drives functional decline rather than just being a marker of neurodegeneration.