Author

Yuefan Deng

Stony Brook UniversityORCID 0000-0002-5224-3958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bertal Huseyin AktasiD· 2 shared Evangelos PapadopoulosiD· 2 shared Georgios KementzidisiD· 2 shared Karin HasegawaiD· 2 shared Evan Xie· 1 shared Justin Burzachiello· 1 shared Liam ConnollyiD· 1 shared Ziyuan NiuiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Bertal Huseyin AktasORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 18, 2024

Structural and Dynamical Analyses of Apo and Cap-binding eIF4E: An in silico Study

Karin Hasegawa, Justin Burzachiello, Liam Connolly…·Yuefan Deng

This study uses molecular dynamics simulations to analyze structural changes in eIF4E when bound to Cap and in its apo form, identifying key residues involved in conformational transitions and suggesting targets for drug design.

DOI 10.1101/2024.05.18.594816

humanprotein structure

BiochemistrybioRxivPreprintMay 15, 2024

An AI-Driven Framework for Discovery of BACE1 Inhibitors for Alzheimer's Disease

Evan Xie, Karin Hasegawa, Georgios Kementzidis…·Yuefan Deng

This paper develops an AI framework to generate and optimize BACE1 inhibitors for Alzheimer's disease, identifying 14 candidates with improved binding properties.

7 citations

humanproteomics