Bertal Huseyin Aktas

This paper develops an ultra-high throughput in vitro translation assay for identifying T. cruzi-specific protein synthesis inhibitors and identifies quinazoline compounds that inhibit translation in both the assay and live parasites.

This study uses molecular dynamics simulations to analyze structural changes in eIF4E when bound to Cap and in its apo form, identifying key residues involved in conformational transitions and suggesting targets for drug design.

This paper develops an AI framework to generate and optimize BACE1 inhibitors for Alzheimer's disease, identifying 14 candidates with improved binding properties.