Volkan I. Sayin

This study shows aging promotes KRAS-driven lung cancer metastasis via ATF4 induction, which can be inhibited by glutaminase blockade.

The paper shows that amino acid restriction increases lung cancer cell sensitivity to ferroptosis by activating GCN2 and the integrated stress response, without affecting glutathione levels.

The paper identifies a novel BACH1 transcriptional signature in lung cancer cells, validated across multiple cell lines, and demonstrates its utility in detecting BACH1 perturbations and identifying inhibitors.

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.