Author

Samantha Alvarez

NYU Langone’s Laura and Isaac Perlmutter Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2

Frequent Co-Authors

Clotilde WieliD· 2 shared Martin Dankis· 2 shared Nadia Gul· 2 shared Volkan I. SayiniD· 2 shared Adolfo Garcı́a-OcañaiD· 1 shared Ahmed Ezat El ZowalatyiD· 1 shared Anders StåhlbergiD· 1 shared Andreas HallqvistiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

Clotilde WielORCID

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3 papers

Recent·Most cited

Aging promotes lung cancer metastasis through epigenetic ATF4 induction

Angana A. H. Patel, Jozefina J. Dzanan, Kevin X. Ali, Ella Äng Eklund, Samantha Alvarez, Dorota Raj, Martin Dankis, Ilayda Altinönder, Maria Schwarz, Kristell Le Gal, Emre Bedel, Ahmed Ezat El Zowalaty, Emma Jonasson, Heba Albatrok, Nadia Gul, , Volkan I. Sayin

This study shows aging promotes KRAS-driven lung cancer metastasis via ATF4 induction, which can be inhibited by glutaminase blockade.

Nature · Mar 11, 2026Peer-reviewedCancer Biology

Amino acid restriction sensitizes lung cancer cells toferroptosis via GCN2-dependent activation of the integratedstress response

Viktor Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, Andreas Persson, Fikret Zahirovic, Clotilde Wiel, Volkan I. Sayin, Per Lindahl

The paper shows that amino acid restriction increases lung cancer cell sensitivity to ferroptosis by activating GCN2 and the integrated stress response, without affecting glutathione levels.

Redox Biology · Dec 24, 2025Peer-reviewedCancer Biology

Acute inhibition of iron-sulfur cluster biosynthesis disrupts metabolic flexibility in mice

Marte Molenaars, Hannan Mir, Samantha Alvarez, Lakshmi Arivazhagan, Carolina Rosselot, Di Zhan, Christopher Y. Park, Adolfo Garcı́a-Ocaña, Ann Marie Schmidt, Richard Possemato

This study shows that acute inhibition of iron-sulfur cluster biosynthesis in mice leads to metabolic inflexibility, reduced adiposity, and glucose dyshomeostasis, with effects mitigated in aged mice.

bioRxiv · Aug 19, 2024 · PreprintPhysiology