Author

Melanie A. McDowell

Max Planck Institute of BiophysicsORCID 0000-0002-5231-8809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:fungi (other)· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Tzu‐Jing YangiD· 2 shared Ahmed-Noor Adam AgipiD· 1 shared Ermanno UboldiiD· 1 shared Gerhard HummeriD· 1 shared Julian D. LangeriD· 1 shared Pamela OrnelasiD· 1 shared Sabine Häder· 1 shared Saumyak MukherjeeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Tzu‐Jing YangORCID

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2 papers

Recent·Most cited

Structures of Chaetomium thermophilum TOM complexes with bound preproteins

Ahmed-Noor Adam Agip, Pamela Ornelas, Tzu‐Jing Yang, Ermanno Uboldi, Sabine Häder, Melanie A. McDowell, Werner Kühlbrandt

The paper presents four structures of the TOM complex from Chaetomium thermophilum, showing its interaction with preproteins and revealing dynamic receptor conformations.

Proceedings of the National Academy of Sciences · Jul 17, 2025Peer-reviewedBiophysics

SND3 is the membrane insertase within a fungal multipass translocon

Tzu‐Jing Yang, Saumyak Mukherjee, Julian D. Langer, Gerhard Hummer, Melanie A. McDowell

This study identifies SND3 as a novel membrane insertase in the fungal SND pathway and presents its structure and mechanism for inserting multipass integral membrane proteins.

bioRxiv · Jul 8, 2025 · PreprintBiophysics