Yuhei Kirita

This study maps epigenetic changes during AKI repair in mice and humans, identifying CREB5 as a regulator of both successful and failed tubular repair.

The paper uses single nucleus RNA sequencing to identify a proinflammatory and profibrotic proximal tubule cell state in mouse AKI that fails to repair, suggesting it as a therapeutic target.

This study uses snRNAseq to analyze early diabetic nephropathy in human kidneys, identifying gene expression changes in potassium secretion and angiogenic signaling across multiple cell types.

CellTag Indexing enables genetic barcode-based multiplexing for single-cell genomics, allowing simultaneous sample identification and transcriptional analysis across diverse cell types.

The paper compares kidney organoid and adult human kidney single-cell and single-nucleus transcriptomes to assess differentiation maturity and identify transcription factor networks.