Wenjun Kong

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

This study shows that inhibiting PTPN1/2 enhances alveolar macrophage anti-metastatic activity through IFN-gamma-STAT1 signaling, offering a therapeutic strategy for metastasis.

This study shows that substrate stiffness affects WI-38 cell proliferation and growth arrest pathways, with soft substrates inducing a unique G1 transcriptional state that is reversed by hTERT expression.

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

The paper uses single-cell RNA sequencing to identify new adipocyte precursor populations and reveals Sox9's role in adipose commitment.

The paper uses CellOracle to analyze GRN reconfiguration during fibroblast to iEP reprogramming, identifying Fos and Yap1 as key factors for successful conversion.

Capybara measures cell identity and fate transitions using a continuum-based approach, showing improved performance in annotating cells and identifying transitions in hematopoiesis and reprogramming.

CellTag Indexing enables genetic barcode-based multiplexing for single-cell genomics, allowing simultaneous sample identification and transcriptional analysis across diverse cell types.

The paper uses single-cell RNA sequencing to show that mice adapt to small bowel resection by reprogramming distal intestinal enterocytes to a proximal identity, driven by retinoid metabolism and Creb3l3.

This paper introduces a lineage-tracing method called CellTagging to study clonal dynamics in direct lineage reprogramming from fibroblasts to induced endoderm progenitors, revealing rare successful reprogramming events and clonal instability.