Macrophage depletion blocks congenital SARM1-dependent neuropathy
Caitlin B. Dingwall, Amy M. Strickland, Sabrina W. Yum, Aldrin Kay‐Yuen Yim, Jian Zhu, Peter L. Wang, Yurie Yamada, Robert E. Schmidt, Yo Sasaki, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
This study shows that macrophage depletion reverses neuropathic symptoms in a mouse model of SARM1-dependent neuropathy caused by NMNAT2 variants.
Journal of Clinical Investigation · Oct 26, 2022Peer-reviewedNeuroscience