Robert E. Schmidt

Widespread sex-biased gene expression reflects female-biased longevity in a species with environmental sex determination

The paper identifies sex-biased gene expression and age-related patterns in painted turtles, linking female-biased longevity to molecular differences without sex chromosomes.

Intestinal stem cells enhance local mucosal immunity through apoptotic body phagocytosis

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.

Macrophage depletion blocks congenital SARM1-dependent neuropathy

This study shows that macrophage depletion reverses neuropathic symptoms in a mouse model of SARM1-dependent neuropathy caused by NMNAT2 variants.

Disruption of lactate metabolism in the peripheral nervous system leads to motor-selective deficits

This study shows that disrupting lactate metabolism in Schwann cells or motor neurons causes motor axon degeneration, while sensory axons remain unaffected, highlighting a specific dependency of motor axons on lactate shuttling.

Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

This study shows that loss of STMN2, linked to TDP-43 pathology in ALS, causes motor neuropathy with NMJ denervation in mice.