Author

Lauren M.F. Merlo

Lankenau Institute for Medical ResearchORCID 0000-0002-5244-6448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Caitlyn E. BowmaniD· 1 shared Cholsoon JangiD· 1 shared Emily T. MirekiD· 1 shared Jiten D. PateliD· 1 shared Joshua D. RabinowitziD· 1 shared Laura Mandik‐NayakiD· 1 shared Megan C. Blair· 1 shared Michael D. NeinastiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Caitlyn E. BowmanORCID

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1 paper

Recent·Most cited

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

Caitlyn E. Bowman, Michael D. Neinast, Ryo Kawakami, Nicholas Forelli, Cholsoon Jang, Jiten D. Patel, Megan C. Blair, Michael Noji, Emily T. Mirek, William O. Jonsson, Qingwei Chu, Lauren M.F. Merlo, Laura Mandik‐Nayak, Tracy Gautsch Anthony, Joshua D. Rabinowitz, Zoltan Pierre Arany

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

Molecular Metabolism · May 8, 2025Peer-reviewedPharmacology & Toxicology