Tracy Gautsch Anthony

Engaging the host adaptive response to nutrient limitation delays cancer cachexia

This study shows that caloric restriction before tumor induction delays cancer cachexia by reducing systemic inflammation and preserving lean mass.

Behavioral dysfunction but not wasting in cancer cachexia is driven by altered tryptophan metabolism

The paper identifies altered tryptophan metabolism in cancer cachexia, showing serotonin depletion and kynurenine accumulation, which drive behavioral dysfunction but not wasting.

Branched-chain amino acid fermentation as an alternative mammalian electron sink

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

Investigating the Synergistic Role of GCN2 and HPA Axis in Regulating Integrated Stress Response in the Central Circadian Timing System

This study investigates the interaction between the circadian system and integrated stress response through a mathematical model, showing GCN2's role in linking ISR with circadian rhythms and its impact on re-entrainment after jetlag.