RAB18 is a key regulator of GalNAc conjugated siRNA induced silencing in Hep3B cells
Jiamiao Lu, Elissa Swearingen, Miki Hardy, Patrick J. Collins, Bin Wu, Eric Yuan, Daniel Lu, Chi-Ming Li, Songli Wang, Michael M. Ollmann
The paper identifies RAB18 as a key regulator that enhances GalNAc-conjugated siRNA efficacy in Hep3B cells by improving siRNA delivery and RISC access.
Molecular Therapy — Nucleic Acids · Apr 2, 2022Peer-reviewedMolecular Biology