Songli Wang

This study shows that hydroxy PEG (OH-PEG) reduces binding to pre-existing anti-PEG antibodies, improving stability and reducing immunogenicity of PEGylated nanomedicines.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

The paper identifies causal genes in heart disease GWAS loci by integrating Hi-C, chromatin accessibility, and transcriptomic data, revealing regulatory relationships in cardiac fibroblasts.

This study presents transcriptomic and proteomic analyses of obesity and T2D in cynomolgus monkeys, identifying tissue-specific molecular changes and potential therapeutic targets.

This paper describes a method to efficiently generate definitive hemogenic endothelium from human pluripotent stem cells, which can differentiate into hematopoietic progenitors and stem cells with multilineage potential.

The paper identifies RAB18 as a key regulator that enhances GalNAc-conjugated siRNA efficacy in Hep3B cells by improving siRNA delivery and RISC access.

This study develops and tests a tBID-based safety switch system for engineered T cells to manage toxicity and persistence, showing up to 90% cell elimination in vitro.

The paper introduces a parallel microscopy system called 96 Eyes that enables simultaneous imaging of all wells on a 96-well plate using Fourier Ptychography to enhance imaging quality and depth of field.

The paper profiles small RNA expression in LPS-stimulated human monocytes and identifies a limited set of miRNAs upregulated during inflammation.