Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment
Máté Kiss, László Halász, Éva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilárd Póliska, Daliya Kancheva, Aurélie AG Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Dániel, , Jo A. Van Ginderachter
This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.
Genome Medicine · Jul 23, 2025Peer-reviewedImmunology