Author

Santosh Paudel

University of MichiganORCID 0000-0002-5266-391XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Harry L. T. MobleyiD· 3 shared Mark T. AndersoniD· 3 shared Geoffrey B. SeveriniD· 2 shared Melanie M. PearsoniD· 2 shared Ali Mohammed PiraniiD· 1 shared Aric N. BrowniD· 1 shared Benjamin E. CurtisiD· 1 shared Bridget S. MoricziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Harry L. T. MobleyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologyInfection and ImmunityPeer-reviewedJul 13, 2026

Cytolethal Distending Toxin Enhances Escherichia coli Urinary Tract Infection

Santosh Paudel, Benjamin E. Curtis, Siena Stefa…·Mark T. Anderson

This study shows that the cytolethal distending toxin (CDT) produced by Escherichia coli enhances urinary tract infection progression by promoting inflammation and tissue damage in mouse models.

DOI 10.1128/iai.00103-26

mouseexperimental assay

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MicrobiologyApplied and Environmental MicrobiologyPeer-reviewedJul 31, 2025

Multiplexed PCR to measure in situ growth rates of uropathogenic E. coli during experimental urinary tract infection.

Santosh Paudel, Geoffrey B. Severin, Ali Mohammed Pirani…·Harry L. T. Mobley

This paper introduces a PCR-based method to measure bacterial growth rates during infection, showing it correlates with WGS-based methods and reveals UPEC growth dynamics in a mouse UTI model.

2 citations

mouseDNA methylation

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MicrobiologyPLoS PathogensPeer-reviewedAug 23, 2024

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

Harry L. T. Mobley, Mark T. Anderson, Bridget S. Moricz…·Michael A. Bachman

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

10 citations

mouseexperimental assay

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