Geoffrey B. Severin

This paper introduces a PCR-based method to measure bacterial growth rates during infection, showing it correlates with WGS-based methods and reveals UPEC growth dynamics in a mouse UTI model.

This study shows that negative feedback of c-di-GMP levels in V. cholerae optimizes switching between sessile and motile lifestyles by regulating PDE expression through VpsR.

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

The paper integrates Tn-Seq fitness data with functional data to identify seven common fitness mechanisms across five Enterobacterales species, validating one gene's role in bacteremia and antibiotic resistance.